I watched the WSGI video (and followed the slides in a second window cause the video is too tiny and compressed) and am sold. WSGI is the future of the Python web framework. While most of the major frameworks (TurboGears, Django, Twisted, et al) support WSGI, only a couple are WSGI from top to bottom: Pylons and Clever Harold. Of these two, Pylons appears to be the most mature and active, so I've decided to give it a shot. Also, the fact that the Pylons crew has ported most of the interesting stuff from Rails doesn't hurt any either.

I have to admit, I'm starting to feel like a framework whore though. Hopefully it starts to pay as well ;-)